TOPOFIT-DB, a database of protein structural alignments based on the TOPOFIT method

Chesley M. Leslin, Alexej Abyzov, Valentin A. Ilyin

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


TOPOFIT-DB (T-DB) is a public web-based database of protein structural alignments based on the TOPOFIT method, providing a comprehensive resource for comparative analysis of protein structure families. The TOPOFIT method is based on the discovery of a saturation point on the alignment curve (topomax point) which presents an ability to objectively identify a border between common and variable parts in a protein structural family, providing additional insight into protein comparison and functional annotation. TOPOFIT also effectively detects non-sequential relations between protein structures. T-DB provides users with the convenient ability to retrieve and analyze structural neighbors for a protein; do one-to-all calculation of a user provided structure against the entire current PDB release with T-Server, and pair-wise comparison using the TOPOFIT method through the T-Pair web page. All outputs are reported in various web-based tables and graphics, with automated viewing of the structure-sequence alignments in the Friend software package for complete, detailed analysis. T-DB presents researchers with the opportunity for comprehensive studies of the variability in proteins and is publicly available at

Original languageEnglish (US)
Pages (from-to)D317-D321
JournalNucleic acids research
Issue numberSUPPL. 1
StatePublished - Jan 2007

ASJC Scopus subject areas

  • Genetics


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