Toll-like receptor-4 and allograft responses

Benjamin Samstein, Geoffrey B. Johnson, Jeffrey L. Platt

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Signaling through toll-like receptors (TLRs) is believed to be the critical first step in the activation of antigen presenting cells and the initiation of adaptive immune responses. Of these receptors, TLR-4 particularly recognizes endogenous agonists and may be important for allograft responses. We tested this concept using mice with defective function and structure of TLR-4 as recipients of grafts across major and minor histocompatibility barriers. The kinetics of rejection was the same in mutant mice and wild-type controls. Our results highlight an important difference between alloimmune and conventional immune responses.

Original languageEnglish (US)
Pages (from-to)475-477
Number of pages3
Issue number3
StatePublished - Feb 15 2004

ASJC Scopus subject areas

  • Transplantation


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