Three dynamin-encoding genes are differentially expressed in developing rat brain

T. Cook, K. Mesa, R. Urrutia

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Dynamin proteins are members of a recently described family of GTPases involved in receptor-mediated processes. To date, three different dynamin- encoding genes have been identified in mammalian tissues. Dynamin I is expressed only in neurons, whereas dynamin II is ubiquitously expressed. A third isoform, dynamin III, was originally isolated from a rat testis cDNA library and shown to be testis-specific. However, here we report the cloning and characterization of dynamin III from brain and lung, demonstrating a more extended pattern of expression for this isoform. In addition, we have investigated the temporal pattern of expression of these three genes during brain development. We find that both dynamin I and dynamin III mRNA levels are up-regulated during embryogenesis, whereas dynamin II mRNA levels remain unchanged. From these results, we conclude that dynamin III is not a testis- specific isoform and, furthermore, that rat brain expresses three different dynamin-encoding genes that are differentially regulated during development. Therefore, this large isoform diversity of dynamin proteins in brain predicts a significant complexity in the understanding of dynamin-based processes in this tissue.

Original languageEnglish (US)
Pages (from-to)927-931
Number of pages5
JournalJournal of neurochemistry
Issue number3
StatePublished - Sep 1996


  • Brain
  • Development
  • Differential expression
  • Dynamin-encoding genes
  • PC12 cells

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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