Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells

Chengfeng Xia; Dapeng Zhou; Chengwen Liu; Yanyan Lou; Qingjia Yao; Wenpeng Zhang; Peng George Wang

doi:10.1021/ol062199b

Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells

Chengfeng Xia, Dapeng Zhou, Chengwen Liu, Yanyan Lou, Qingjia Yao, Wenpeng Zhang, Peng George Wang

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to α-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biological assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3.

Original language	English (US)
Pages (from-to)	5493-5496
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	24
DOIs	https://doi.org/10.1021/ol062199b
State	Published - Nov 23 2006

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol062199b

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abstract = "Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to α-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biological assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3.",

author = "Chengfeng Xia and Dapeng Zhou and Chengwen Liu and Yanyan Lou and Qingjia Yao and Wenpeng Zhang and Wang, {Peng George}",

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AU - Xia, Chengfeng

AU - Zhou, Dapeng

AU - Liu, Chengwen

AU - Lou, Yanyan

AU - Yao, Qingjia

AU - Zhang, Wenpeng

AU - Wang, Peng George

PY - 2006/11/23

Y1 - 2006/11/23

N2 - Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to α-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biological assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3.

AB - Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to α-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biological assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3.

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ER -

Thio-isoglobotrihexosylceramide, an agonist for activating invariant natural killer T cells

Abstract

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