Therapeutic radiation and hyperparathyroidism. A case-control study in Rochester, Minn

C. M. Beard, H. Heath, W. M. O'Fallon, J. A. Anderson, J. D. Earle, L. J. Melton

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


A case-control study was conducted among residents of Rochester, Minn, to assess the influence of prior therapeutic radiation on the risk of primary hyperparathyrodism. Fifty-one cases of surgically proven primary hyperparathyroidism diagnosed from 1975 through 1983 were each matched by age and gender to two control subjects, with radiation exposure documented through preexisting medical records. The overall odds ratio for any prior therapeutic radiation therapy was 1.9 (95% confidence interval, 0.9 to 4.4) and it was 2.3 (95% confidence interval, 0.9 to 5.7) when limited to those with prior head and neck radiation. Among women, the figures were 2.9 (95% confidence interval, 1.1 to 7.5) for any prior therapeutic radiation and 3.4 (95% confidence interval, 1.2 to 10.2) for head and neck exposure. This study confirms the association between primary hyperparathyroidism and prior therapeutic radiation exposure, at least for women in this population.

Original languageEnglish (US)
Pages (from-to)1887-1890
Number of pages4
JournalArchives of internal medicine
Issue number8
StatePublished - 1989

ASJC Scopus subject areas

  • Internal Medicine


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