The Zollinger-Ellison syndrome - A collective surgical experience

David R. Farley, Jon A. Van Heerden, Clive S. Grant, Laurence J. Miller, Duane M. Ilstrup

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


A retrospective study of 90 surgically treated patients with the Zollinger-Ellison syndrome seen from 1958 through 1990 was performed. Fifteen patients had Zollinger-Ellison syndrome as a manifestation of multiple endocrine neoplasia type I. Preoperative tumor localization was positive in 46% of 54 patients studied. Gastrinomas were identified in 66% of patients, 38% of the tumors being malignant. Postoperative eugastrinemia was achieved in 11% of patients after a variety of surgical procedures. Exploratory laparotgmy provides the only chance for cure and identifies the significant prognostic factors associated with long-term patient survival: small tumor size, extrapancreatic primary, and absence of tumor metastases.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalAnnals of surgery
Issue number6
StatePublished - 1992

ASJC Scopus subject areas

  • Surgery


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