The young brain and concussion: Imaging as a biomarker for diagnosis and prognosis

Esteban Toledo, Alyssa Lebel, Lino Becerra, Anna Minster, Clas Linnman, Nasim Maleki, David W. Dodick, David Borsook

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations


Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.

Original languageEnglish (US)
Pages (from-to)1510-1531
Number of pages22
JournalNeuroscience and Biobehavioral Reviews
Issue number6
StatePublished - Jul 2012


  • Adolescents
  • Autonomic
  • Brain
  • Brain imaging
  • Children
  • Cognitive
  • Concussion
  • Cortex
  • FMRI
  • Hypothalamus
  • TBI

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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