THE Y CHROMOSOME IN SPERM OF AN XYY MALE

Robert B. Diasio; Robert H. Glass

doi:10.1016/S0140-6736(70)92286-5

THE Y CHROMOSOME IN SPERM OF AN XYY MALE

Robert B. Diasio, Robert H. Glass

Pharmacology

Research output: Contribution to journal › Letter › peer-review

4 Scopus citations

Original language	English (US)
Pages (from-to)	1318-1319
Number of pages	2
Journal	The Lancet
Volume	296
Issue number	7686
DOIs	https://doi.org/10.1016/S0140-6736(70)92286-5
State	Published - Dec 19 1970

ASJC Scopus subject areas

Medicine(all)

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10.1016/S0140-6736(70)92286-5

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@article{75c7ac69e16849aab5d48db041775d9d,

title = "THE Y CHROMOSOME IN SPERM OF AN XYY MALE",

author = "Diasio, {Robert B.} and Glass, {Robert H.}",

note = "Funding Information: HBO 200 light source, BG 12 excitor filter, barrier filter, and an oil objective. 1000 spermatozoa were counted, and of these approxi- mately 70% contained one F-body, approximately 5% contained two F-bodies, and the rest contained no obvious F-bodies. When two F-bodies were present they appeared as distinct fluorescent spots which tended to line up in the longitudinal axis of the sperm head. Usually, one of the two was brighter; this perhaps was due to their relative depth within the sperm head. The size of the F-bodies within a sperm head were approximately equal. They were located relatively close together, but they did not appear contiguous. A typical sperm with two F-bodies is shown in the accompanying figure. Since no technique is at present available for selectively staining the X chromosome in sperm, we cannot be certain of the percentage carrying the XY chromosomal comple-ment. These are probably represented in the group containing one F-body. The finding of a small but significant number of sperm possessing two F-bodies raises the question of whether another explanation of the sex ratio in the progeny of XYY males should be invoked. Rather than considering the meiotic stage as providing an elimination mechanism, perhaps the selectivity lies in the sperm{\textquoteright}s journey to the egg, and in the sperm{\textquoteright}s {"} fitness to get there first. This work was supported by a grant from the Ford Foundation. Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.",

year = "1970",

month = dec,

day = "19",

doi = "10.1016/S0140-6736(70)92286-5",

language = "English (US)",

volume = "296",

pages = "1318--1319",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "7686",

}

TY - JOUR

T1 - THE Y CHROMOSOME IN SPERM OF AN XYY MALE

AU - Diasio, Robert B.

AU - Glass, Robert H.

N1 - Funding Information: HBO 200 light source, BG 12 excitor filter, barrier filter, and an oil objective. 1000 spermatozoa were counted, and of these approxi- mately 70% contained one F-body, approximately 5% contained two F-bodies, and the rest contained no obvious F-bodies. When two F-bodies were present they appeared as distinct fluorescent spots which tended to line up in the longitudinal axis of the sperm head. Usually, one of the two was brighter; this perhaps was due to their relative depth within the sperm head. The size of the F-bodies within a sperm head were approximately equal. They were located relatively close together, but they did not appear contiguous. A typical sperm with two F-bodies is shown in the accompanying figure. Since no technique is at present available for selectively staining the X chromosome in sperm, we cannot be certain of the percentage carrying the XY chromosomal comple-ment. These are probably represented in the group containing one F-body. The finding of a small but significant number of sperm possessing two F-bodies raises the question of whether another explanation of the sex ratio in the progeny of XYY males should be invoked. Rather than considering the meiotic stage as providing an elimination mechanism, perhaps the selectivity lies in the sperm’s journey to the egg, and in the sperm’s " fitness to get there first. This work was supported by a grant from the Ford Foundation. Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.

PY - 1970/12/19

Y1 - 1970/12/19

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U2 - 10.1016/S0140-6736(70)92286-5

DO - 10.1016/S0140-6736(70)92286-5

M3 - Letter

C2 - 4098814

AN - SCOPUS:0014955511

SN - 0140-6736

VL - 296

SP - 1318

EP - 1319

JO - The Lancet

JF - The Lancet

IS - 7686

ER -

THE Y CHROMOSOME IN SPERM OF AN XYY MALE

ASJC Scopus subject areas

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