The Siblings With Ischemic Stroke Study (SWISS): A progress report

James F. Meschia, Brett M. Kissela, Thomas G. Brott, Robert D. Brown, Bradford B. Worrall, Jeanne Beck, Alexa N. Skarp

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


There is increasing evidence that genetic factors are associated with ischemic stroke, including multiple recent reports of association with the gene PDE4D, encoding phosphodiesterase 4D, on chromosome 5q12. Genetic studies of stroke are important but can be logistically difficult to perform. This article reviews the design of the Siblings With Ischemic Stroke Study (SWISS) and discusses problems in performing a sibling-based pedigree study where proband-initiated consent is used to enroll pedigree members. Proband-initiated enrollment optimizes privacy protections for family members, but it is associated with a substantial pedigree non-completion rate such that 3 to 4 probands must be identified to obtain one completed sibling pedigree. This report updates the progress of enrollment in the SWISS protocol, discusses barriers to pedigree completion and describes innovative approaches used by the SWISS investigators to enhance enrollment.

Original languageEnglish (US)
Pages (from-to)12-21
Number of pages10
JournalClinical Medicine and Research
Issue number1
StatePublished - Mar 2006


  • Cerebral infarction
  • Ischemic stroke
  • Pedigree research
  • Proband
  • Recruitment

ASJC Scopus subject areas

  • Community and Home Care


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