The search for treatments to reduce chemotherapy-induced peripheral neuropathy

Deirdre R. Pachman, Charles L. Loprinzi, Axel Grothey, Lauren E. Ta

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Oxaliplatin, a commonly used chemotherapeutic agent, is associated with both acute and chronic neurotoxicity. Chronic sensory neuropathy can be dose limiting and may have detrimental effects on patients' quality of life. Preclinical studies provide an understanding of the pathophysiology of chemotherapy- induced peripheral neuropathy (CIPN) and may be important for developing effective preventative interventions. In this issue of the JCI, Coriat and colleagues used an animal model and a human pilot trial to evaluate the use of mangafodipir to reduce CIPN. Although many pilot clinical studies have reported promising data, larger clinical trials have repeatedly been unable to confirm these preliminary results. Thus, no agents are currently clinically recommended for the prevention of CIPN.

Original languageEnglish (US)
Pages (from-to)72-74
Number of pages3
JournalJournal of Clinical Investigation
Issue number1
StatePublished - Jan 2 2014

ASJC Scopus subject areas

  • General Medicine


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