The role of soy phytoestrogens in prostate cancer

Erik P. Castle, J. Brantley Thrasher

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


Epidemiological data of phytoestrogens and prostate cancer strongly supports the cancer protective effects of isoflavones found in soy products. Inhibition of cell proliferation via hormone-dependent and hormone-independent mechanisms by soy phytochemicals has been studied extensively in cell culture and animal studies. Herein, we review the current literature on the epidemiology and effects of two soy phytoestrogens, genistein and daidzein, and would stress the need for controlled human trials to assess the true preventive and therapeutic effects of these compounds.

Original languageEnglish (US)
Pages (from-to)71-81
Number of pages11
JournalUrologic Clinics of North America
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Urology


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