The role of endothelin in coronary atherosclerosis

Verghese Mathew, David Hasdai, Amir Lerman

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


During the evolution of coronary atherosclerosis, growth factors, cytokines, and other molecules are involved in cell recruitment, migration, and proliferation. Endothelin is an endothelial-derived vasoconstrictor peptide that possesses mitogenic properties. In this review, current evidence is provided that suggests that endothelin fulfills proposed criteria to be considered an atherogenic peptide because of its mitogenic and proliferative properties, as well as its inter-actions with known atherogenic factors. In addition, a proposed role of endothelin in the evolution of atherosclerosis is outlined.

Original languageEnglish (US)
Pages (from-to)769-777
Number of pages9
JournalMayo Clinic proceedings
Issue number8
StatePublished - 1996

ASJC Scopus subject areas

  • General Medicine


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