The prognostic value of cardiopulmonary exercise testing in idiopathic pulmonary fibrosis

Charlene D. Fell, Lyrica Xiaohong Liu, Caroline Motika, Ella A. Kazerooni, Barry H. Gross, William D. Travis, Thomas V. Colby, Susan Murray, Galen B. Toews, Fernando J. Martinez, Kevin R. Flaherty

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Rationale: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea, impaired gas exchange, and ultimate mortality. Objectives: To test the hypothesis that maximal oxygen uptake during cardiopulmonary exercise testing at baseline and with short-term longitudinal measures would predict mortality in patients with idiopathic pulmonary fibrosis. Methods: Data from 117 patients with IPF and longitudinal cardiopulmonary exercise tests were examined retrospectively. Survival was calculated from the date of the first cardiopulmonary exercise test. Measurements and Main Results: Patients with baseline maximal oxygen uptake less than 8.3 ml/kg/min had an increased risk of death (n = 8; hazard ratio, 3.24; 95% confidence interval, 1.10-9.56; P = 0.03) after adjusting for age, gender, smoking status, baseline forced vital capacity, and baseline diffusion capacity for carbon monoxide. We were unable to define a unit change in maximal oxygen uptake that predicted survival in our cohort. Conclusions:We conclude that a threshold maximal oxygen uptake of 8.3 ml/kg/min during cardiopulmonary exercise testing at baseline adds prognostic information for patients with IPF.

Original languageEnglish (US)
Pages (from-to)402-407
Number of pages6
JournalAmerican journal of respiratory and critical care medicine
Issue number5
StatePublished - Mar 1 2009


  • Exercise test
  • Idiopathic pulmonary fibrosis
  • Mortality

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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