The pathology of primary progressive multiple sclerosis

Claudia Lucchinetti, Wolfgang Bruck

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


The pathological hallmark of chronic multiple sclerosis includes focal demyelination, gliosis, inflammation and axonal injury. There is limited information on whether these pathological features differ across the clinical phenotypes of the disease (relapsing-remitting, secondary progressive, and primary progressive). This review will focus on the pathological aspects of PPMS and pathogenic implications. A better understanding of the differences in PPMS pathology and pathogenesis will lead to more effective treatment strategies.

Original languageEnglish (US)
Pages (from-to)S23-S30
JournalMultiple Sclerosis
Issue numberSUPPL. 1
StatePublished - Jun 2004


  • Axons
  • Multiple sclerosis
  • Myelin
  • Oligodendrocytes
  • Pathology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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