The pathogenesis of chronic myeloproliferative diseases

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9 Scopus citations


Chronic myeloproliferative disorders are operationally classified to include essential thrombocythemia, polycythemia vera, and agnogenic myeloid metaplasia. In most cases, clonal hematopoiesis, involving all 3 myeloid lineages, can be demonstrated. However, the underlying molecular lesions that are responsible for disease initiation and progression remain elusive. There are ongoing efforts to clarify the pathogenetic role of cytokines, bone marrow stromal cells and molecules, and intracellular aberrations in either signal transduction or apoptosis. This review discusses some of the current and past observations regard-ing the pathogenesis of chronic myeloproliferative disorders.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalInternational journal of hematology
Issue number2
StatePublished - Jan 1 2001


  • Agnogenic myeloid metaplasia
  • Chronic myeloproliferative disease
  • Essential thrombocythemia
  • Polycythemia vera

ASJC Scopus subject areas

  • Hematology


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