The Microbiome in Crohn's Disease. Role in Pathogenesis and Role of Microbiome Replacement Therapies

Sahil Khanna; Laura E. H. Raffals

doi:10.1016/j.gtc.2017.05.004

The Microbiome in Crohn's Disease. Role in Pathogenesis and Role of Microbiome Replacement Therapies

Sahil Khanna, Laura E. H. Raffals

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Individuals with a genetic predisposition to Crohn disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of Crohn disease. Decrease in global gut microbial diversity and specific bacterial alterations have been implicated in Crohn disease. Advances in sequencing techniques and bioinformatics and correlation with host genetics continue to improve insight into the structure and function of the microbial community and interactions with the host immune system. This article summarizes the existing literature on the role of the gut microbiome and its manipulation in development and management of Crohn disease.

Original language	English (US)
Journal	Gastroenterology Clinics of North America
DOIs	https://doi.org/10.1016/j.gtc.2017.05.004
State	Accepted/In press - 2017

Keywords

Crohn's disease
Fecal microbiota transplantation
Gut microbiota
Inflammatory bowel disease
Microbiome
Pathogenesis
Probiotics

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.gtc.2017.05.004

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abstract = "Individuals with a genetic predisposition to Crohn disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of Crohn disease. Decrease in global gut microbial diversity and specific bacterial alterations have been implicated in Crohn disease. Advances in sequencing techniques and bioinformatics and correlation with host genetics continue to improve insight into the structure and function of the microbial community and interactions with the host immune system. This article summarizes the existing literature on the role of the gut microbiome and its manipulation in development and management of Crohn disease.",

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AB - Individuals with a genetic predisposition to Crohn disease develop aberrant immune responses to environmental triggers. The gastrointestinal microbiota is increasingly recognized to play an important role in the development of Crohn disease. Decrease in global gut microbial diversity and specific bacterial alterations have been implicated in Crohn disease. Advances in sequencing techniques and bioinformatics and correlation with host genetics continue to improve insight into the structure and function of the microbial community and interactions with the host immune system. This article summarizes the existing literature on the role of the gut microbiome and its manipulation in development and management of Crohn disease.

KW - Crohn's disease

KW - Fecal microbiota transplantation

KW - Gut microbiota

KW - Inflammatory bowel disease

KW - Microbiome

KW - Pathogenesis

KW - Probiotics

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The Microbiome in Crohn's Disease. Role in Pathogenesis and Role of Microbiome Replacement Therapies

Abstract

Keywords

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