The Mechanobiology of Vascular Remodeling in the Aging Lung

Paul B. Dieffenbach, Aja Aravamudhan, Laura E. Fredenburgh, Daniel J. Tschumperlin

Research output: Contribution to journalReview articlepeer-review


Aging is accompanied by declining lung function and increasing susceptibility to lung diseases. The role of endothelial dysfunction and vascular remodeling in these changes is supported by growing evidence, but underlying mechanisms remain elusive. In this review we summarize functional, structural, and molecular changes in the aging pulmonary vasculature and explore how inter-acting aging and mechanobiological cues may drive progressive vascular remodeling in the lungs.

Original languageEnglish (US)
Pages (from-to)28-38
Number of pages11
Issue number1
StatePublished - Jan 2022


  • Matrix
  • Pulmonary
  • Senescence
  • Stiffness
  • Vessel

ASJC Scopus subject areas

  • Physiology


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