TY - JOUR
T1 - The impact of alcohol on breathing parameters during sleep
T2 - A systematic review and meta-analysis
AU - Kolla, Bhanu Prakash
AU - Foroughi, Moein
AU - Saeidifard, Farzane
AU - Chakravorty, Subhajit
AU - Wang, Zhen
AU - Mansukhani, Meghna P.
N1 - Funding Information:
MPM is the principal investigator on a research grant funded by ResMed Corporation and a benefactor-sponsored career development award at Mayo Clinic, Rochester, Minnesota, that are unrelated to the current study. The authors would like to thank Patricia Erwin, MLS, for her assistance with designing the search strategy and performing the literature search. The authors would also like to thank J. Todd Arnedt, PhD, for providing additional data for inclusion in the meta analyses.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/12
Y1 - 2018/12
N2 - Alcohol, a muscle relaxant, can potentially worsen obstructive sleep apnea (OSA) but the literature on the effects of alcohol on OSA is conflicting. This systematic review and meta-analysis of randomized controlled trials examined the impact of alcohol on breathing parameters during sleep. Ovid Medline, Embase and PsycINFO databases were queried through November 1, 2017 for studies that reported objective measures of breathing during sleep, prior to and after alcohol administration. Weighted mean differences (WMD) and 95% confidence intervals (CI) were calculated for apnea-hypopnea index (AHI) and mean oxyhemoglobin saturation (SpO2). Secondary outcome measures were examined where available. The meta-analysis of 14 eligible studies (n = 422; 71.9% male) found that AHI increased significantly after alcohol administration (WMD = 2.33; 95% CI = 1.41 to 3.25, I2 = 62%) and mean SpO2 was significantly reduced (WMD = −0.60; 95% CI = −0.72 to −0.49, I2 = 0%). The increase in AHI was greater in snorers (WMD = 4.20; 95% CI = 1.19 to 6.50, I2 = 0%) and those with a diagnosis of OSA (WMD = 7.10; 95% CI = 3.59 to 10.61, I2 = 0%). Additionally, a significant increase in respiratory event duration (WMD = 0.86; 95% CI = 0.18 to 1.55, I2 = 19%) and decrease in nadir SpO2 (WMD = −1.25; 95% CI = −2.00 to −0.50, I2 = 25%) were noted. Alcohol is a modifiable risk factor that can result in the development or worsening of OSA.
AB - Alcohol, a muscle relaxant, can potentially worsen obstructive sleep apnea (OSA) but the literature on the effects of alcohol on OSA is conflicting. This systematic review and meta-analysis of randomized controlled trials examined the impact of alcohol on breathing parameters during sleep. Ovid Medline, Embase and PsycINFO databases were queried through November 1, 2017 for studies that reported objective measures of breathing during sleep, prior to and after alcohol administration. Weighted mean differences (WMD) and 95% confidence intervals (CI) were calculated for apnea-hypopnea index (AHI) and mean oxyhemoglobin saturation (SpO2). Secondary outcome measures were examined where available. The meta-analysis of 14 eligible studies (n = 422; 71.9% male) found that AHI increased significantly after alcohol administration (WMD = 2.33; 95% CI = 1.41 to 3.25, I2 = 62%) and mean SpO2 was significantly reduced (WMD = −0.60; 95% CI = −0.72 to −0.49, I2 = 0%). The increase in AHI was greater in snorers (WMD = 4.20; 95% CI = 1.19 to 6.50, I2 = 0%) and those with a diagnosis of OSA (WMD = 7.10; 95% CI = 3.59 to 10.61, I2 = 0%). Additionally, a significant increase in respiratory event duration (WMD = 0.86; 95% CI = 0.18 to 1.55, I2 = 19%) and decrease in nadir SpO2 (WMD = −1.25; 95% CI = −2.00 to −0.50, I2 = 25%) were noted. Alcohol is a modifiable risk factor that can result in the development or worsening of OSA.
KW - Alcohol
KW - Oxygen saturation
KW - Sleep apnea
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U2 - 10.1016/j.smrv.2018.05.007
DO - 10.1016/j.smrv.2018.05.007
M3 - Review article
C2 - 30017492
AN - SCOPUS:85049729859
SN - 1087-0792
VL - 42
SP - 59
EP - 67
JO - Sleep Medicine Reviews
JF - Sleep Medicine Reviews
ER -