The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

David Engel, Tom Seijkens, Marjorie Poggi, Maryam Sanati, Larissa Thevissen, Linda Beckers, Erwin Wijnands, Dirk Lievens, Esther Lutgens

Research output: Contribution to journalReview articlepeer-review


Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalSeminars in immunology
Issue number5
StatePublished - Oct 2009


  • Atherosclerosis
  • CD154
  • CD40
  • Co-stimulation
  • Inflammation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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