The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

David Engel; Tom Seijkens; Marjorie Poggi; Maryam Sanati; Larissa Thevissen; Linda Beckers; Erwin Wijnands; Dirk Lievens; Esther Lutgens

doi:10.1016/j.smim.2009.06.004

The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

David Engel, Tom Seijkens, Marjorie Poggi, Maryam Sanati, Larissa Thevissen, Linda Beckers, Erwin Wijnands, Dirk Lievens, Esther Lutgens

Cardiovascular Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.

Original language	English (US)
Pages (from-to)	308-312
Number of pages	5
Journal	Seminars in immunology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/j.smim.2009.06.004
State	Published - Oct 2009

Keywords

Atherosclerosis
CD154
CD40
Co-stimulation
Inflammation

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.smim.2009.06.004

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title = "The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis",

abstract = "Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.",

keywords = "Atherosclerosis, CD154, CD40, Co-stimulation, Inflammation",

author = "David Engel and Tom Seijkens and Marjorie Poggi and Maryam Sanati and Larissa Thevissen and Linda Beckers and Erwin Wijnands and Dirk Lievens and Esther Lutgens",

note = "Funding Information: This work was supported by the Humboldt Foundation (Sofja Kovalevskaja grant to EL), the Netherlands Organization for Scientific Research (VIDI grant to EL), the Netherlands Heart Foundation (Dr. E. Dekker grant to EL and DL).",

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doi = "10.1016/j.smim.2009.06.004",

language = "English (US)",

volume = "21",

pages = "308--312",

journal = "Seminars in immunology",

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T1 - The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

AU - Engel, David

AU - Seijkens, Tom

AU - Poggi, Marjorie

AU - Sanati, Maryam

AU - Thevissen, Larissa

AU - Beckers, Linda

AU - Wijnands, Erwin

AU - Lievens, Dirk

AU - Lutgens, Esther

N1 - Funding Information: This work was supported by the Humboldt Foundation (Sofja Kovalevskaja grant to EL), the Netherlands Organization for Scientific Research (VIDI grant to EL), the Netherlands Heart Foundation (Dr. E. Dekker grant to EL and DL).

PY - 2009/10

Y1 - 2009/10

N2 - Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.

AB - Atherosclerosis is a chronic disease of the large arteries that is responsible for the majority of cardiovascular events. In its pathogenesis, the immune system plays a pivotal role. The effectuation of the immune response through interactions between immune cells that is mediated by co-stimulatory molecules, determine atherosclerosis severity. This review will highlight the role of one of the most powerful co-stimulatory dyads, the CD154 (also known as CD40 ligand, CD40L)-CD40 dyad, in atherosclerosis. Its cell-type specific actions, signal transduction cascades and its therapeutic potentials will be discussed.

KW - Atherosclerosis

KW - CD154

KW - CD40

KW - Co-stimulation

KW - Inflammation

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SN - 1044-5323

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JO - Seminars in immunology

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The immunobiology of CD154-CD40-TRAF interactions in atherosclerosis

Abstract

Keywords

ASJC Scopus subject areas

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