The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

D. Herminghuysen; C. Cook; H. Thompson; D. Bostick; F. Lee; L. Stokes; C. Hilton; C. Prasad

doi:10.1016/0143-4179(94)90082-5

The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

D. Herminghuysen, C. Cook, H. Thompson, D. Bostick, F. Lee, L. Stokes, C. Hilton, C. Prasad

Endocrinology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in order to characterize the secretory pattern of CHP during a 24 h fast. Four subjects (2 obese and 2 lean) were studied during the latter 24 h of a 36 h fast. Blood was sampled every 10-15 min and assayed for CHP concentration using a specific radioimmunoassay. Analysis revealed that circulating CHP oscillates in humans and that diurnal variation occurred but only in the obese subjects.

Original language	English (US)
Pages (from-to)	273-280
Number of pages	8
Journal	Neuropeptides
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/0143-4179(94)90082-5
State	Published - Apr 1994

ASJC Scopus subject areas

Endocrinology
Neurology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

Access to Document

10.1016/0143-4179(94)90082-5

Cite this

@article{8fe1a20065bb4474939db5b1bcee2edc,

title = "The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans",

abstract = "Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in order to characterize the secretory pattern of CHP during a 24 h fast. Four subjects (2 obese and 2 lean) were studied during the latter 24 h of a 36 h fast. Blood was sampled every 10-15 min and assayed for CHP concentration using a specific radioimmunoassay. Analysis revealed that circulating CHP oscillates in humans and that diurnal variation occurred but only in the obese subjects.",

author = "D. Herminghuysen and C. Cook and H. Thompson and D. Bostick and F. Lee and L. Stokes and C. Hilton and C. Prasad",

year = "1994",

month = apr,

doi = "10.1016/0143-4179(94)90082-5",

language = "English (US)",

volume = "26",

pages = "273--280",

journal = "Neuropeptides",

issn = "0143-4179",

publisher = "Churchill Livingstone",

number = "4",

}

TY - JOUR

T1 - The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

AU - Herminghuysen, D.

AU - Cook, C.

AU - Thompson, H.

AU - Bostick, D.

AU - Lee, F.

AU - Stokes, L.

AU - Hilton, C.

AU - Prasad, C.

PY - 1994/4

Y1 - 1994/4

N2 - Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in order to characterize the secretory pattern of CHP during a 24 h fast. Four subjects (2 obese and 2 lean) were studied during the latter 24 h of a 36 h fast. Blood was sampled every 10-15 min and assayed for CHP concentration using a specific radioimmunoassay. Analysis revealed that circulating CHP oscillates in humans and that diurnal variation occurred but only in the obese subjects.

AB - Histidyl-proline diketopiperazine (CHP) is a cyclic dipeptide that is found in many animal tissues, most notably brain and gut. It has been found to have a variety of biologic actions and has been postulated to play a role in appetitive behavior and energy metabolism. This study was conducted in order to characterize the secretory pattern of CHP during a 24 h fast. Four subjects (2 obese and 2 lean) were studied during the latter 24 h of a 36 h fast. Blood was sampled every 10-15 min and assayed for CHP concentration using a specific radioimmunoassay. Analysis revealed that circulating CHP oscillates in humans and that diurnal variation occurred but only in the obese subjects.

UR - http://www.scopus.com/inward/record.url?scp=0028355293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028355293&partnerID=8YFLogxK

U2 - 10.1016/0143-4179(94)90082-5

DO - 10.1016/0143-4179(94)90082-5

M3 - Article

C2 - 8028717

AN - SCOPUS:0028355293

SN - 0143-4179

VL - 26

SP - 273

EP - 280

JO - Neuropeptides

JF - Neuropeptides

IS - 4

ER -

The gut-brain peptide cyclo(His-Pro) is secreted in a pulsatile fashion in fasting humans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this