@article{1b2fabe6cbd9498983d33442cd6c56eb,
title = "The future of cancer immunotherapy for brain tumors: a collaborative workshop",
abstract = "Harnessing the effector mechanisms of the immune system to combat brain tumors with antigen specificity and memory has been in research and clinical testing for many years. Government grant mechanisms and non-profit organizations have supported many innovative projects and trials while biotech companies have invested in the development of needed tools, assays and novel clinical approaches. The National Brain Tumor Society and the Parker Institute for Cancer Immunotherapy partnered to host a workshop to share recent data, ideas and identify both hurdles and new opportunities for harnessing immunotherapy against pediatric and adult brain tumors. Adoptively transferred cell therapies have recently shown promising early clinical results. Local cell delivery to the brain, new antigen targets and innovative engineering approaches are poised for testing in a new generation of clinical trials. Although several such advances have been made, several obstacles remain for the successful application of immunotherapies for brain tumors, including the need for more representative animal models that can better foreshadow human trial outcomes. Tumor and tumor microenvironment biopsies with multiomic analysis are critical to understand mechanisms of response and patient stratification, yet brain tumors are especially challenging for such biopsy collection. These workshop proceedings and commentary shed light on the status of immunotherapy in pediatric and adult brain tumor patients, including current research as well as opportunities for improving future efforts to bring immunotherapy to the forefront in the management of brain tumors.",
keywords = "Brain tumors, Cell therapy, Immunotherapy",
author = "Brown, {Christine E.} and Samantha Bucktrout and Butterfield, {Lisa H.} and Olga Futer and Evanthia Galanis and Adilia Hormigo and Michael Lim and Hideho Okada and Robert Prins and Marr, {Sara Siebel} and Kirk Tanner",
note = "Funding Information: Funding was provided by the Parker Institute for Cancer Immunotherapy and the National Brain Tumor Society. Partial editorial support was obtained with E-squared. Funding Information: LHB declares the following unrelated scientific advisory activities: Calidi 2017-present; Khloris, 2019-present; Pyxis, 2019-present; Cytomix, 2019-present; DCprime, 2020–21; RAPT, 2020-present; Takeda, 2020-present; EnaraBio, 2021. AH declares the following unrelated scientific advisory activity: TargTex 2020-present, receives research support from Novocure, EMD Serono, National Brain Tumor Society{\textquoteright}s Defeat Brain Tumors Program and StacheStrong Foundation, and is the recipient of the Cancer Research Institute − V Foundation CLIP Grant (CRI Award # 3680). ML reports the following unrelated activities: Research Support − Arbor, BMS, Accuray, Tocagen, Biohaven, Kyrin-Kyowa, Biohaven; Consultant − Tocagen, VBI, InCephalo Therapeutics, Pyramid Bio, Merck, BMS, Insightec, Biohaven, Sanianoia, Hemispherian, Black Diamond Therapeutics, Novocure; Shareholder – Egret Therapeutics; Patent − focused radiation + checkpoint inhibitors, local chemotherapy + checkpoint inhibitors, checkpoints for neuro-inflammation; Non-Research Consultant–Stryker. CEB receives patent revenue and research support from MustangBio and Chimeric Therapeutics, and unrelated advisory activities for Aleta Biotherapeutics, Poseida Therapeutics and Pluto Immunotherapeutics. SB reports unrelated scientific advisory position with Apertor Therapeutics; EG reports the following activities: Consulting/Advisory Role – Gradalis, Inc. (personal compensation); Kiyatec, Inc. (personal compensation) Karyopharm Therapeutics, Inc. (compensation to institution) & Research/Grant/Clinical Trial Funding—Servier Pharmaceuticals LCC (formerly Agios Pharmaceuticals) (Inst); Celgene (Inst); MedImmune, Inc. (Inst); Tracon Pharmaceuticals (Inst). Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = dec,
doi = "10.1186/s12967-022-03438-z",
language = "English (US)",
volume = "20",
journal = "Journal of Translational Medicine",
issn = "1479-5876",
publisher = "BioMed Central",
number = "1",
}