The Effect of Penicillamine on Serum Digoxin Levels

Bahram Moezzi, Vahab Fatourechi, Roholah Khozain, Bahrain Eslami

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The effect of 1 Gm of penicillamine (pen) on serum digoxin levels (SDLs) of 3 groups of patients (Pts) on maintenance digoxin therapy was studied. Each group served as its own control. Group I (10pts) had serum digoxin measurements (SDMs) 2, 4, and 6 hours (hrs) after receiving their daily oral doses of digoxin. The next day SDMs were made similarly following 1 Gm of pen 2 hrs after administration of digoxin. In all pts the SDLs were significantly lower 2, 4, and 6hrs after receiving pen (1.86±0.25 VS 1.62±0.22, 1.80±0.17 VS 1.44±0.26, 1.87±0.27 VS 1.14±0.24 ng/ml, mean±SD with respective p values <0.025, <0.005 and <0.001). In order to exclude the interference of pen on digoxin absorption, Group II (13pts) had SDMs 22 hrs after their last oral doses of digoxin before and 6hrs after receiving 1 Gm of pen. In this group SDLs were also significantly reduced (1.50±0.48 VS 1.16±0.51 ng/ml, mean±SD, p <0.05). Group III (10pts) received maintenance intravenous digoxin for 5 days prior to SDM. In this group also marked reduction of SDM was observed 4 and 6hrs following 1 Gm of pen (1.36±0.50 VS 1.04±0.40, 1.46±0.69 VS 0.50±0.64ng/ml, mean±SD with p values of <0.001 and <0.005, respectively). It can be concluded that oral penicillamine reduces SDL significantly in digitalized pts irrespective of the route of digoxin administration and may be of significant value in management of digitalis toxicity.

Original languageEnglish (US)
Pages (from-to)366-370
Number of pages5
JournalJapanese Heart Journal
Issue number3
StatePublished - 1978


  • Digitalis intoxication
  • Penicillamine
  • Serum digoxin level
  • Serum digoxin measurement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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