The Effect of Nicotine Patch Therapy on Depression in Nonsmokers: A Preliminary Study

Lisa Sanderson Cox; Christi A. Patten; Lois E. Krahn; Richard D. Hurt; Ivana T. Croghan; Troy D. Wolter; Darrell R. Schroeder; Diane Tri; Kenneth P. Offord

doi:10.1300/J069v22n04_07

The Effect of Nicotine Patch Therapy on Depression in Nonsmokers: A Preliminary Study

Lisa Sanderson Cox, Christi A. Patten, Lois E. Krahn, Richard D. Hurt, Ivana T. Croghan, Troy D. Wolter, Darrell R. Schroeder, Diane Tri, Kenneth P. Offord

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Prior uncontrolled studies of nonsmokers with major depressive disorder (MDD) indicate rapid reduction in depressive symptoms with nicotine patch therapy. This randomized, double-blind, placebo-controlled pilot study examined the effect of nicotine patch therapy on depressive symptoms in non-medicated nonsmokers with current MDD. Due to recruitment difficulties, only 7 were enrolled and of these 6 (5 females, 1 male) completed the study. Participants received either placebo (n = 4) or active (n = 2) patch therapy for 8 days. They completed daily clinic visits during patch therapy and a final visit on Day 12. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HRSD). The mean change in HRSD scores of all participants decreased (p = 0.021) from baseline by Day 1 of patch use. Similar decreases in HRSD scores were observed for placebo and active patch groups. Among the placebo participants, the mean HRSD score decreased (p = 0.038) by Day 2. The study needs replication with a larger sample and utilizing novel recruitment strategies.

Original language	English (US)
Pages (from-to)	75-85
Number of pages	11
Journal	Journal of Addictive Diseases
Volume	22
Issue number	4
DOIs	https://doi.org/10.1300/J069v22n04_07
State	Published - 2003

Keywords

Depression
Nicotine
Nicotine patch therapy
Smoking

ASJC Scopus subject areas

Medicine (miscellaneous)
Clinical Psychology
Psychiatry and Mental health

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10.1300/J069v22n04_07

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title = "The Effect of Nicotine Patch Therapy on Depression in Nonsmokers: A Preliminary Study",

abstract = "Prior uncontrolled studies of nonsmokers with major depressive disorder (MDD) indicate rapid reduction in depressive symptoms with nicotine patch therapy. This randomized, double-blind, placebo-controlled pilot study examined the effect of nicotine patch therapy on depressive symptoms in non-medicated nonsmokers with current MDD. Due to recruitment difficulties, only 7 were enrolled and of these 6 (5 females, 1 male) completed the study. Participants received either placebo (n = 4) or active (n = 2) patch therapy for 8 days. They completed daily clinic visits during patch therapy and a final visit on Day 12. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HRSD). The mean change in HRSD scores of all participants decreased (p = 0.021) from baseline by Day 1 of patch use. Similar decreases in HRSD scores were observed for placebo and active patch groups. Among the placebo participants, the mean HRSD score decreased (p = 0.038) by Day 2. The study needs replication with a larger sample and utilizing novel recruitment strategies.",

keywords = "Depression, Nicotine, Nicotine patch therapy, Smoking",

author = "{Sanderson Cox}, Lisa and Patten, {Christi A.} and Krahn, {Lois E.} and Hurt, {Richard D.} and Croghan, {Ivana T.} and Wolter, {Troy D.} and Schroeder, {Darrell R.} and Diane Tri and Offord, {Kenneth P.}",

note = "Funding Information: This study was supported by a clinical research grant #1526-98 from the Mayo Clinic and Mayo Foundation.",

year = "2003",

doi = "10.1300/J069v22n04_07",

language = "English (US)",

volume = "22",

pages = "75--85",

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AU - Hurt, Richard D.

AU - Croghan, Ivana T.

AU - Wolter, Troy D.

AU - Schroeder, Darrell R.

AU - Tri, Diane

AU - Offord, Kenneth P.

N1 - Funding Information: This study was supported by a clinical research grant #1526-98 from the Mayo Clinic and Mayo Foundation.

PY - 2003

Y1 - 2003

N2 - Prior uncontrolled studies of nonsmokers with major depressive disorder (MDD) indicate rapid reduction in depressive symptoms with nicotine patch therapy. This randomized, double-blind, placebo-controlled pilot study examined the effect of nicotine patch therapy on depressive symptoms in non-medicated nonsmokers with current MDD. Due to recruitment difficulties, only 7 were enrolled and of these 6 (5 females, 1 male) completed the study. Participants received either placebo (n = 4) or active (n = 2) patch therapy for 8 days. They completed daily clinic visits during patch therapy and a final visit on Day 12. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HRSD). The mean change in HRSD scores of all participants decreased (p = 0.021) from baseline by Day 1 of patch use. Similar decreases in HRSD scores were observed for placebo and active patch groups. Among the placebo participants, the mean HRSD score decreased (p = 0.038) by Day 2. The study needs replication with a larger sample and utilizing novel recruitment strategies.

AB - Prior uncontrolled studies of nonsmokers with major depressive disorder (MDD) indicate rapid reduction in depressive symptoms with nicotine patch therapy. This randomized, double-blind, placebo-controlled pilot study examined the effect of nicotine patch therapy on depressive symptoms in non-medicated nonsmokers with current MDD. Due to recruitment difficulties, only 7 were enrolled and of these 6 (5 females, 1 male) completed the study. Participants received either placebo (n = 4) or active (n = 2) patch therapy for 8 days. They completed daily clinic visits during patch therapy and a final visit on Day 12. Depressive symptoms were assessed using the Hamilton Rating Scale for Depression (HRSD). The mean change in HRSD scores of all participants decreased (p = 0.021) from baseline by Day 1 of patch use. Similar decreases in HRSD scores were observed for placebo and active patch groups. Among the placebo participants, the mean HRSD score decreased (p = 0.038) by Day 2. The study needs replication with a larger sample and utilizing novel recruitment strategies.

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The Effect of Nicotine Patch Therapy on Depression in Nonsmokers: A Preliminary Study

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