The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and dna replicationcoupled nucleosome assembly in budding yeast

Rebecca J. Burgess; Junhong Han; Zhiguo Zhang

doi:10.1074/jbc.M114.552463

The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and dna replicationcoupled nucleosome assembly in budding yeast

Rebecca J. Burgess, Junhong Han, Zhiguo Zhang

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Background: Genome stability is maintained in part by chromatin structure and checkpoint factors. Results: Yeast cells harboring mutations in the Ddc1-Mec3-Rad17 checkpoint complex exhibit synthetic phenotypes with histone chaperone mutants. Conclusion: The Ddc1-Mec3-Rad17 complex regulates nucleosome assembly. Significance: Checkpoint factors and histone chaperones coordinate to maintain genome integrity.

Original language	English (US)
Pages (from-to)	10518-10529
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	15
DOIs	https://doi.org/10.1074/jbc.M114.552463
State	Published - Apr 11 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.552463

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title = "The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and dna replicationcoupled nucleosome assembly in budding yeast",

abstract = "Background: Genome stability is maintained in part by chromatin structure and checkpoint factors. Results: Yeast cells harboring mutations in the Ddc1-Mec3-Rad17 checkpoint complex exhibit synthetic phenotypes with histone chaperone mutants. Conclusion: The Ddc1-Mec3-Rad17 complex regulates nucleosome assembly. Significance: Checkpoint factors and histone chaperones coordinate to maintain genome integrity.",

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AU - Han, Junhong

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AB - Background: Genome stability is maintained in part by chromatin structure and checkpoint factors. Results: Yeast cells harboring mutations in the Ddc1-Mec3-Rad17 checkpoint complex exhibit synthetic phenotypes with histone chaperone mutants. Conclusion: The Ddc1-Mec3-Rad17 complex regulates nucleosome assembly. Significance: Checkpoint factors and histone chaperones coordinate to maintain genome integrity.

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The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and dna replicationcoupled nucleosome assembly in budding yeast

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