@article{4a0d62d587ca45b8bf4911a3bf7dfaa2,
title = "The chromosome 9 ALS and FTD locus is probably derived from a single founder",
abstract = "We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all populations and that several families previously shown to have genetic linkage to this region also share this haplotype. The most parsimonious explanation of these data are that there is a single founder for this form of disease.",
keywords = "Amyotrophic lateral sclerosis, Finland, Frontotemporal dementia, Genetics",
author = "Kin Mok and Traynor, {Bryan J.} and Jennifer Schymick and Tienari, {Pentti J.} and Hannu Laaksovirta and Terhi Peuralinna and Liisa Myllykangas and Adriano Chi{\`o} and Aleksey Shatunov and Boeve, {Bradley F.} and Boxer, {Adam L.} and Mariely DeJesus-Hernandez and Mackenzie, {Ian R.} and Adrian Waite and Nigel Williams and Morris, {Huw R.} and Javier Sim{\'o}n-S{\'a}nchez and {van Swieten}, {John C.} and Peter Heutink and Gabriella Restagno and Gabriele Mora and Morrison, {Karen E.} and Shaw, {Pamela J.} and Rollinson, {Pamela Sara} and Ammar Al-Chalabi and Rosa Rademakers and Stuart Pickering-Brown and Orrell, {Richard W.} and Nalls, {Michael A.} and John Hardy",
note = "Funding Information: This work was supported in part by the Intramural Research Programs of the NIH, the National Institute on Aging ( Z01-AG000949-02 ), and the National Institute on Neurological Disorders and Stroke . Extramural NIH grants R01AG031278 , R01AG038791 supported some family assessments: NIH/NIA grant R01 AG26251 (RR) funded some analytical work. The research leading to these results has received funding from the European Community's Health Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 259867. The authors thank the Motor Neurone Disease Association of Great Britain for several grants relating to this work (RWO, AAC, PJS, HM), the ALS Association, The Angel Fund, the ALS Therapy Alliance, and the Wellcome Trust (PJS) for support.This work was also funded by the Reta Lila Weston Foundation, and by an MRC returning scientist (JH) and fellowship (SPB) award, by Microsoft Research Foundation, the ALS Association, Helsinki University Central Hospital, and the Finnish Academy. This work was also funded by Ministero della Salute, Progetti Finalizzati 2007, Fondazione Vialli e Mauro for ALS, and Federazione Italiana Giuoco Calcio. The authors also thank the Hersenstichting Nederland ( www.hersenstichting.nl ) for supporting this work. The authors thank the NIHR specialist Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust (SLaM) and the Institute of Psychiatry, King's College London as well as the NIHR-funded UCL/UCLH Comprehensive Biomedical Research Centre. ",
year = "2012",
month = jan,
doi = "10.1016/j.neurobiolaging.2011.08.005",
language = "English (US)",
volume = "33",
pages = "209.e3--209.e8",
journal = "Neurobiology of aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "1",
}