The cephalosporins

William F. Marshall, Jams E. Blair

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


The cephalosporins are a large group of related β-lactam antimicrobial agents. Favorable attributes of the cephalosporins include low rates of toxicity, relatively broad spectrum of activity, and ease of administration. Various cephalosporins are effective for treatment of many conditions, including pneumonia, skin and soft tissue infections, bacteremia, and meningitis. Differences among the numerous cephalosporin antimicrobial agents are sometimes subtle; however, an understanding of these differences is essential for optimal use of these agents. As a result of widespread use of cephalosporins, bacterial resistance to these drugs is increasingly common. New, fourth-generation agents (such as cefepime) offer an alternative for the treatment of infections caused by some drug-resistant microorganisms.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalMayo Clinic proceedings
Issue number2
StatePublished - 1999

ASJC Scopus subject areas

  • General Medicine


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