@article{3f759e17ccb44a5585d0de2841eec49a,
title = "The association between Self-Reported Medication Adherence scores and systolic blood pressure control: a SPRINT baseline data study",
abstract = "We examined baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT) to investigate whether medication adherence, measured by the 8-item Morisky Medication Adherence Scale (MMAS-8), was associated with systolic blood pressure (SBP) and whether MMAS-8 score and number of antihypertensive medications interacted in influencing SBP. A total of 8435 SPRINT participants were included: 21.2% had low adherence (MMAS-8: <6); 40.0% had medium adherence (6 to <8); and 38.8% had high adherence (8). SBP was <140 mm Hg in 54.6%; 140–160 mm Hg in 36.6%; and >160 mm Hg in 8.8%. In multivariable regression, medium vs. low adherence weakly associated with lower SBP (odds ratio: 1.17; confidence interval: 1.04, 1.31). SPRINT eligibility criteria should be considered when interpreting results. Efforts to understand and enhance adherence are crucial to improve population health, and using self-report instruments might be considered for predicting treatment adherence and response in future efficacy trials and for identifying patients for adherence support in clinical practice.",
keywords = "Clinical trial, MMAS-8, hypertension",
author = "{SPRINT Study Research Group} and Haley, {William E.} and Gilbert, {Olivia N.} and Riley, {Robert F.} and Newman, {Jill C.} and Roumie, {Christianne L.} and Jeffrey Whittle and Kronish, {Ian M.} and Leonardo Tamariz and Alan Wiggers and Morisky, {Donald E.} and Conroy, {Molly B.} and Eugene Kovalik and Kressin, {Nancy R.} and Paul Muntner and Goff, {David C.}",
note = "Funding Information: The authors also acknowledge the support from the following CTSAs funded by NCATS: Funding Information: The Systolic Blood Pressure Intervention Trial is funded with Federal funds from the National Institutes of Health (NIH), including the National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS), under contract numbers HHSN268200900040C , HHSN268200900046C , HHSN268200900047C , HHSN268200900048C , HHSN268200900049C , and Inter-Agency Agreement Number A-HL-13-002-001. It was also supported in part with resources and use of facilities through the Department of Veterans Affairs . Ian Kronish, MD, MPH; I.M.K. was supported by grants K23 HL098359 and R01 HL123368 from NHLBI . Publisher Copyright: {\textcopyright} 2016 American Society of Hypertension",
year = "2016",
month = nov,
day = "1",
doi = "10.1016/j.jash.2016.08.009",
language = "English (US)",
volume = "10",
pages = "857--864.e2",
journal = "Journal of the American Society of Hypertension",
issn = "1933-1711",
publisher = "Elsevier Ireland Ltd",
number = "11",
}