Targeting the adaptive immune system: New strategies in the treatment of atherosclerosis

Barbara Zarzycka, Gerry A.F. Nicolaes, Esther Lutgens

Research output: Contribution to journalReview articlepeer-review


Atherosclerosis is a lipid-driven chronic inflammatory disease of the arterial wall. Current treatment of atherosclerosis is focused on limiting its risk factors, such as hyperlipidemia or hypertension. However, treatments that target the inflammatory nature of atherosclerosis are still under development. Discovery of novel targets involved in the inflammation of the arterial wall creates opportunities to design new therapeutics that successfully modulate atherosclerosis. Here, we review drug targets that have proven to play pivotal roles in the adaptive immune system in atherosclerosis, and we discuss their potential as novel therapeutics.

Original languageEnglish (US)
Pages (from-to)297-313
Number of pages17
JournalExpert review of clinical pharmacology
Issue number3
StatePublished - May 1 2015


  • adaptive immune system
  • atherosclerosis
  • drug discovery
  • target identification

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • Pharmacology (medical)


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