@article{ef7f1cbddb5643c8aeeba452447d2a5d,
title = "Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities",
abstract = "Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle arrest after experiencing inherent or environmental stresses. Although cellular senescence is essential in several physiological events, it plays a detrimental role in a large array of age-related pathologies. Recent biomedical advances in specifically targeting senescent cells to improve healthy aging, or alternatively, postpone natural aging and age-related diseases, a strategy termed senotherapy, have attracted substantial interest in both scientific and medical communities. Challenges for aging research are highlighted and potential avenues that can be leveraged for therapeutic interventions to control aging and age-related disorders in the current era of precision medicine.",
keywords = "aging, clinical trials, healthspan, senescent cells, senolytics, senotherapy",
author = "Shuling Song and Tamara Tchkonia and Jing Jiang and Kirkland, {James L.} and Yu Sun",
note = "Funding Information: S.S, T.T., and J.J. contributed equally to this work. The authors sincerely apologize to colleagues whose work in aging, cellular senescence, and geriatric medicine could not be cited due to space restrictions. The authors are grateful to members of the Sun Laboratory for inspiring discussions and insightful comments. This work is supported in part by grants from the National Key Research and Development Program of China (2020YFC2002801, 2016YFC1302400), the Strategic Priority Research Program of Chinese Academy of Sciences (XDB39010500), the National Natural Science Foundation of China (NSFC) (81472709, 31671425, 31871380), the fund of Key Lab of Tissue Microenvironment and Tumor of Chinese Academy of Sciences (201506, 201706, 202008), the program of Shanghai Academic/Technology Research Leader of the Science and Technology Commission of Shanghai Municipality (20XD1404300), Antiaging Collaborative Program of SIBS and BY-HEALTH (C01201911260006), the University and Locality Collaborative Development Program of Yantai (2019XDRHXMRC08), and the U.S. Department of Defense (DoD) Prostate Cancer Research Program (PCRP) (Idea Development Award PC111703) to Y.S.; and the U.S. National Institutes of Health grants R37-AG013925 and P01 AG062413, the Connor Fund, Robert J. and Theresa W. Ryan, and the Noaber Foundation to J.L.K. [Correction after publication on 02 December 2020: In the Figure 1 caption, the last sentence was removed as it was a repetition of the preceding sentence. In the Acknowledgements, the funding for the National Key Research and Development Program of China, (2016YFC130202400, 2019YFC2002801) was corrected to (2020YFC2002801, 2016YFC1302400).] Funding Information: S.S, T.T., and J.J. contributed equally to this work. The authors sincerely apologize to colleagues whose work in aging, cellular senescence, and geriatric medicine could not be cited due to space restrictions. The authors are grateful to members of the Sun Laboratory for inspiring discussions and insightful comments. This work is supported in part by grants from the National Key Research and Development Program of China (2016YFC1302400, 2019YFC2002801), the Strategic Priority Research Program of Chinese Academy of Sciences (XDB39010500), the National Natural Science Foundation of China (NSFC) (81472709, 31671425, 31871380), the fund of Key Lab of Tissue Microenvironment and Tumor of Chinese Academy of Sciences (201506, 201706, 202008), the program of Shanghai Academic/Technology Research Leader of the Science and Technology Commission of Shanghai Municipality (20XD1404300), Antiaging Collaborative Program of SIBS and BY‐HEALTH (C01201911260006), the University and Locality Collaborative Development Program of Yantai (2019XDRHXMRC08), and the U.S. Department of Defense (DoD) Prostate Cancer Research Program (PCRP) (Idea Development Award PC111703) to Y.S.; and the U.S. National Institutes of Health grants R37‐AG013925 and P01 AG062413, the Connor Fund, Robert J. and Theresa W. Ryan, and the Noaber Foundation to J.L.K. Publisher Copyright: {\textcopyright} 2020 The Authors. Published by Wiley-VCH GmbH",
year = "2020",
month = dec,
day = "2",
doi = "10.1002/advs.202002611",
language = "English (US)",
volume = "7",
journal = "Advanced Science",
issn = "2198-3844",
publisher = "Wiley-VCH Verlag",
number = "23",
}