Systemic Polyarteritis Nodosa

Research output: Chapter in Book/Report/Conference proceedingChapter


Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis predominantly affecting the medium-sized arteries with widely variable presenting features, disease course, and outcomes. Recent updates regarding the nomenclature of PAN have resulted in the description of several PAN sub-phenotypes. Herein discussed are idiopathic PAN, Hepatitis B-associated PAN and monogenic disorders such as adenosine deaminase-2 deficiency. The current understanding of the pathogenesis, histopathological features, and treatment of these conditions are reviewed.

Original languageEnglish (US)
Title of host publicationRare Diseases of the Immune System
PublisherSpringer Nature
Number of pages19
StatePublished - 2021

Publication series

NameRare Diseases of the Immune System
ISSN (Print)2282-6505
ISSN (Electronic)2283-6403


  • Adenosine deaminase 2 deficiency
  • Autoimmunity
  • Hepatitis B
  • Polyarteritis nodosa
  • Vasculitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Genetics(clinical)


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