Synthesis of 14 (R,S)‐[18F]fluoro‐6‐thia‐heptadecanoic acid (FTHA)

Timothy R. Degrado

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


No‐carrier‐added (n.c.a) 14(R,S)‐[18F]fluoro‐6‐thia‐heptadecanoic acid (FTHA) has been synthesized for evaluation as a PET tracer for myocardial long chain fatty acid utilization. The n.c.a. nucleophilic radiofluorination of benzyl 14(R,S)‐tosyloxy‐6‐thia‐heptadecanoate in acetonitrile utilized (cryptate 2.2.2/K)2CO3 for anion activation. The resulting [18F]fluoro‐ester was quantitatively hydrolyzed with addition of aqueous KOH and the product purified by reversed phase HPLC. The radiochemical yield of purified FTHA was 35–65% (n=5) with a synthesis time of 50 min. Radiochemical purity was >99%.

Original languageEnglish (US)
Pages (from-to)989-995
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number9
StatePublished - Sep 1991


  • F
  • nucleophilic radiofluorination
  • thia fatty acid

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry


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