Synthesis and immunostimulatory activity of substituted TLR7 agonists

Babatope Akinbobuyi, Lei Wang, Katherine C. Upchurch, Matthew R. Byrd, Charles A. Chang, Jeremy M. Quintana, Rachel E. Petersen, Zacharie J. Seifert, José R. Boquin, Sang Kon Oh, Robert R. Kane

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Fifteen new substituted adenines were synthesized as potential TLR7 agonists. These compounds, along with 9 previously reported compounds, were analyzed for TLR7 activity and for the selective stimulation of B cell proliferation. Several functionalized derivatives exhibit significant activity, suggesting their potential for use as vaccine adjuvants.

Original languageEnglish (US)
Pages (from-to)4246-4249
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number17
StatePublished - 2016


  • Adenine derivatives
  • Immune activation
  • Toll-like receptor
  • Vaccines

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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