TY - JOUR
T1 - Suppressive and enhancing T cell factors as I region gene products
T2 - properties and the subregion assignment Origins of Lymphocyte Diversity
AU - Tada, T.
AU - Taniguchi, M.
AU - David, C. S.
PY - 1976/1/1
Y1 - 1976/1/1
N2 - Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.
AB - Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.
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U2 - 10.1101/sqb.1977.041.01.016
DO - 10.1101/sqb.1977.041.01.016
M3 - Article
C2 - 302186
AN - SCOPUS:0017204474
SN - 0091-7451
VL - 41
SP - 119
EP - 127
JO - Cold Spring Harbor Symposia on Quantitative Biology
JF - Cold Spring Harbor Symposia on Quantitative Biology
IS - 1
ER -