Two distinct antigen-specific T-cell factors having opposite functions in the regulation of antibody response are described, one suppressive and the other enhancing for a T-cell-dependent antibody response. Both factors are found to have I-region gene expressions. Available evidence indicates that they are coded for by genes present in distinct I subregions, and that the targets for these factors are probably T cells also carrying I-region determinants. Incorporating the new target cell type in the network of immunocompetent cell interactions, possible mechanisms of T-cell mediated regulation of antibody response are discussed.
|Original language||English (US)|
|Number of pages||9|
|Journal||Cold Spring Harbor Symposia on Quantitative Biology|
|State||Published - Jan 1 1976|
ASJC Scopus subject areas
- Molecular Biology