Succinate dehydrogenase loss in familial paraganglioma: Biochemistry, genetics, and epigenetics

Yeng F. Her; L. James Maher

doi:10.1155/2015/296167

Succinate dehydrogenase loss in familial paraganglioma: Biochemistry, genetics, and epigenetics

Yeng F. Her, L. James Maher

Biochemistry and Molecular Biology

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.

Original language	English (US)
Article number	296167
Journal	International Journal of Endocrinology
Volume	2015
DOIs	https://doi.org/10.1155/2015/296167
State	Published - 2015

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems

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title = "Succinate dehydrogenase loss in familial paraganglioma: Biochemistry, genetics, and epigenetics",

abstract = "It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.",

author = "Her, {Yeng F.} and Maher, {L. James}",

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N2 - It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.

AB - It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.

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Succinate dehydrogenase loss in familial paraganglioma: Biochemistry, genetics, and epigenetics

Abstract

ASJC Scopus subject areas

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