Strains from both theiler's virus subgroups encode a determinant for demyelination

Jianlin Fu, Moses Rodriguez, Raymond P. Roos

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The GDVII strain and other nenvers of the GDVII subgroup of Theiler's viruses (TMEV) cause an acute Iethal neuronal infection in mice, whereas the DA other members of the TO subgroup of TMEY cause a chronic demyelinating disease associated with a infection. We used GDVII/DA chimeric infectious cDNAs to viruses in order to for the TMEV in activity. We found that both the GDVII DA strains contain a genetic determinant (s) for demelimating activity No Demyeliatin occurs follwing GdvII strain inoculation because ant strain strains contain a genetic derenbant (s) for demyelinating activity. No demyuelination occurs following GDVIIprodusd determinants) for ctivity. No following GDVII strain inoculation because this strain produces and eary neuronal disease that kills micematter de thean early kills before white matter desease and persistent infection can occur.

Original languageEnglish (US)
Pages (from-to)6345-6348
Number of pages4
JournalJournal of virology
Volume64
Issue number12
StatePublished - 1990

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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