Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou; Xingxing Zhu; Chaofan Li; Yanfeng Li; Zhenqing Ye; Virginia Smith Shapiro; John A. Copland; Taro Hitosugi; David A. Bernlohr; Jie Sun; Hu Zeng

doi:10.1016/j.celrep.2020.108601

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Xian Zhou
, Xingxing Zhu
, Chaofan Li
, Yanfeng Li
, Zhenqing Ye
, Virginia Smith Shapiro
, John A. Copland
, Taro Hitosugi
, David A. Bernlohr
, Jie Sun
, Hu Zeng

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.

Original language	English (US)
Article number	108601
Journal	Cell reports
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.108601
State	Published - Jan 5 2021

Keywords

B cell
autophagy
humoral immunity
mTOR
monounsaturated fatty acid
stearoyl-CoA desaturase

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108601

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title = "Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity",

abstract = "Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.",

keywords = "B cell, autophagy, humoral immunity, mTOR, monounsaturated fatty acid, stearoyl-CoA desaturase",

author = "Xian Zhou and Xingxing Zhu and Chaofan Li and Yanfeng Li and Zhenqing Ye and Shapiro, \{Virginia Smith\} and Copland, \{John A.\} and Taro Hitosugi and Bernlohr, \{David A.\} and Jie Sun and Hu Zeng",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2021",

month = jan,

day = "5",

doi = "10.1016/j.celrep.2020.108601",

language = "English (US)",

volume = "34",

journal = "Cell reports",

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TY - JOUR

T1 - Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

AU - Zhou, Xian

AU - Zhu, Xingxing

AU - Li, Chaofan

AU - Li, Yanfeng

AU - Ye, Zhenqing

AU - Shapiro, Virginia Smith

AU - Copland, John A.

AU - Hitosugi, Taro

AU - Bernlohr, David A.

AU - Sun, Jie

AU - Zeng, Hu

PY - 2021/1/5

Y1 - 2021/1/5

N2 - Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.

AB - Zhou et al. show that monounsaturated fatty acids (MUFAs), generated by stearoyl-CoA desaturase (SCD), support B cell mitochondrial metabolism and mTOR activity and promote B cell development and humoral immune responses. These data establish MUFA availability as a key regulator for humoral immunity and a potential therapeutic target.

KW - B cell

KW - autophagy

KW - humoral immunity

KW - mTOR

KW - monounsaturated fatty acid

KW - stearoyl-CoA desaturase

UR - https://www.scopus.com/pages/publications/85098624688

UR - https://www.scopus.com/pages/publications/85098624688#tab=citedBy

U2 - 10.1016/j.celrep.2020.108601

DO - 10.1016/j.celrep.2020.108601

M3 - Article

C2 - 33406440

AN - SCOPUS:85098624688

SN - 2211-1247

VL - 34

JO - Cell reports

JF - Cell reports

IS - 1

M1 - 108601

ER -

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Abstract

Keywords

ASJC Scopus subject areas

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