Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: A pooled analysis of 4500 patients

Salil V. Deo; Abeer Rababa'h; Salah E. Altarabsheh; Ju Yong Lim; Yang Hyun Cho; Soon J. Park

doi:10.1016/j.hlc.2014.04.007

Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: A pooled analysis of 4500 patients

Salil V. Deo, Abeer Rababa'h, Salah E. Altarabsheh, Ju Yong Lim, Yang Hyun Cho, Soon J. Park

Cardiovascular Surgery

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I²=41%; p-value for heterogeneity=0.13}.

Original language	English (US)
Pages (from-to)	985-987
Number of pages	3
Journal	Heart Lung and Circulation
Volume	23
Issue number	10
DOIs	https://doi.org/10.1016/j.hlc.2014.04.007
State	Published - Oct 1 2014

Keywords

Dilated cardiomyopathy
Heart failure
HydroxylglutarylCoA reductase inhibitiors
Non-ischemic cardiomyopathy
Statin

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/j.hlc.2014.04.007

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title = "Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: A pooled analysis of 4500 patients",

abstract = "Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I2=41%; p-value for heterogeneity=0.13}.",

keywords = "Dilated cardiomyopathy, Heart failure, HydroxylglutarylCoA reductase inhibitiors, Non-ischemic cardiomyopathy, Statin",

author = "Deo, {Salil V.} and Abeer Rababa'h and Altarabsheh, {Salah E.} and Lim, {Ju Yong} and Cho, {Yang Hyun} and Park, {Soon J.}",

note = "Publisher Copyright: {\textcopyright} 2014 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ).",

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doi = "10.1016/j.hlc.2014.04.007",

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T2 - A pooled analysis of 4500 patients

AU - Deo, Salil V.

AU - Rababa'h, Abeer

AU - Altarabsheh, Salah E.

AU - Lim, Ju Yong

AU - Cho, Yang Hyun

AU - Park, Soon J.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I2=41%; p-value for heterogeneity=0.13}.

AB - Statin therapy has demonstrated a beneficial effect in patients with chronic heart failure. While the majority of patients with ischaemic cardiomyopathy are prescribed these drugs, studies have demonstrated that less than one fifth of patients with dilated cardiomyopathy are on regular statin therapy. We have performed a meta-analysis of 4500 patients from six studies (four randomised controlled trials). Our results demonstrate that statin therapy significantly improves long-term survival in patients with non-ischaemic heart failure {Hazard ratio for mortality 0.45 (0.33-0.62); p<0.0001; I2=41%; p-value for heterogeneity=0.13}.

KW - Dilated cardiomyopathy

KW - Heart failure

KW - HydroxylglutarylCoA reductase inhibitiors

KW - Non-ischemic cardiomyopathy

KW - Statin

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Statin therapy improves long-term survival in non-ischaemic cardiomyopathy: A pooled analysis of 4500 patients

Abstract

Keywords

ASJC Scopus subject areas

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