Spontaneous coronary artery dissection: etiology and recurrence

Nicholas Y. Tan, Marysia S. Tweet

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Introduction: Spontaneous coronary artery dissection (SCAD) is an increasingly appreciated cause of acute myocardial infarction (AMI) and sudden cardiac death most often affecting young to middle-aged women with few conventional cardiovascular risk factors. Areas covered: A literature search was performed using MedLine, PubMed, and Google Scholar (dating to 04/30/2019). Authors review the key clinical features of SCAD and highlight what is known regarding its pathophysiology and associated factors. The relationship between SCAD and other systemic vasculopathies, notably fibromuscular dysplasia (FMD) is also discussed. Authors also mention the management of acute SCAD along with considerations for long term follow-up such as chest pain syndrome, extracoronary vasculopathy screening, and recurrent SCAD. Expert opinion: Our understanding regarding the association of SCAD and other arteriopathies such as FMD is anticipated to grow. In addition, progress is likely to be made in our efforts to predict recurrent SCAD risk and define potential preventative strategies, possibly through the incorporation of adjunctive imaging.

Original languageEnglish (US)
Pages (from-to)497-510
Number of pages14
JournalExpert Review of Cardiovascular Therapy
Issue number7
StatePublished - Jul 3 2019


  • Spontaneous coronary artery dissection
  • acute coronary syndrome
  • fibromuscular dysplasia
  • myocardial infarction
  • women’s health

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine


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