Spine Disorders and Regenerative Rehabilitation

Eva Kubrova, Andre J. van Wijnen, Wenchun Qu

Research output: Contribution to journalReview articlepeer-review


Purpose of Review: The purpose of this review is to evaluate recent advancements in regenerative medicine modalities in the treatment of the most common spinal disorders. Recent Findings: Immunomodulatory and trophic effects of the mesenchymal stem cells (MSCs), platelet-rich plasma (PRP), and growth factors have been studied in the treatment of symptomatic degenerative spine disorders including degenerative disc disease and facet joint arthropathy. Gene therapy and exosomes are investigated as a future generation of biologics with gene therapy most advanced in the treatment of osteoarthritis. Summary: While current studies have shown benefit in pain and function using MSCs and PRP treatment for common spine conditions, high-quality controlled clinical trials are needed for assessing the safety and effectiveness of biologics.

Original languageEnglish (US)
Pages (from-to)30-36
Number of pages7
JournalCurrent Physical Medicine and Rehabilitation Reports
Issue number1
StatePublished - Mar 1 2020


  • Degenerative disc
  • Facet joint
  • Gene therapy
  • Growth factors
  • Mesenchymal stem cells
  • Platelet-rich plasma

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine


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