Spectrum of Restrictive and Infiltrative Cardiomyopathies: Part 2 of a 2-Part Series

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15 Scopus citations


Restrictive cardiomyopathies are the least common form of heart muscle disease. They are characterized as infiltrative and noninfiltrative, storage diseases, and endomyocardial disorders. Genetic diseases commonly present during childhood or adolescence. However, a growing percentage of elderly patients with heart failure with preserved ejection fraction are being recognized as having forms of restrictive cardiomyopathy, particularly cardiac amyloidosis. Noninvasive evaluation has replaced endomyocardial biopsy in the diagnostic evaluation of most suspected etiologies. The detection of infiltrative cardiomyopathies, particularly primary and secondary forms of iron overload, as well as inflammatory diseases such as sarcoidosis has slowly led to improved outcomes via disease-specific therapies.

Original languageEnglish (US)
Pages (from-to)1149-1166
Number of pages18
JournalJournal of the American College of Cardiology
Issue number10
StatePublished - Mar 13 2018


  • heart failure
  • restrictive cardiomyopathy
  • sarcoidosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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