Snake neurotoxins: Effect of disulfide reduction on interaction with electroplax

Eva Bartels; Terrone L. Rosenberry

doi:10.1126/science.174.4015.1236

Snake neurotoxins: Effect of disulfide reduction on interaction with electroplax

Eva Bartels, Terrone L. Rosenberry

Neuroscience

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3′-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.

Original language	English (US)
Pages (from-to)	1236-1237
Number of pages	2
Journal	Science
Volume	174
Issue number	4015
DOIs	https://doi.org/10.1126/science.174.4015.1236
State	Published - 1971

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title = "Snake neurotoxins: Effect of disulfide reduction on interaction with electroplax",

abstract = "Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3′-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.",

author = "Eva Bartels and Rosenberry, {Terrone L.}",

year = "1971",

doi = "10.1126/science.174.4015.1236",

language = "English (US)",

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pages = "1236--1237",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - Snake neurotoxins

T2 - Effect of disulfide reduction on interaction with electroplax

AU - Bartels, Eva

AU - Rosenberry, Terrone L.

PY - 1971

Y1 - 1971

N2 - Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3′-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.

AB - Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3′-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.

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M3 - Article

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AN - SCOPUS:0015230662

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SP - 1236

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JO - Science

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ER -

Snake neurotoxins: Effect of disulfide reduction on interaction with electroplax

Abstract

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