Smoking-Related Diffuse Cystic Lung Disease

Nishant Gupta, Thomas V. Colby, Cristopher A. Meyer, Francis X. McCormack, Kathryn A. Wikenheiser-Brokamp

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Exposure to cigarette smoke can lead to a variety of parenchymal lung diseases, including diffuse cystic lung diseases (DCLDs). Lymphangioleiomyomatosis (LAM) is the prototypical DCLD and has a characteristic appearance on high-resolution CT (HRCT). We present a series of four patients with DCLD on HRCT who were referred to our institution with a presumed diagnosis of LAM and who were found instead to have smoking-related injury of the small airways on histopathological analysis. We submit that cigarette smoke–induced small airway injury can present as DCLD on HRCT in a pattern that can mimic LAM. A detailed history of cigarette smoke exposure should be obtained in patients presenting with DCLD, and imaging features should not be used in isolation to establish a firm diagnosis of LAM.

Original languageEnglish (US)
Pages (from-to)e31-e35
Issue number2
StatePublished - Aug 2018

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine


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