TY - JOUR
T1 - Sleep disturbances in early alcohol recovery
T2 - Prevalence and associations with clinical characteristics and severity of alcohol consumption
AU - Kolla, Bhanu Prakash
AU - Mansukhani, Meghna P.
AU - Biernacka, Joanna
AU - Chakravorty, Subhajit
AU - Karpyak, Victor M.
N1 - Funding Information:
Results reported in this study were based on the data collected for the NIH/NIAAA grant P20 1P20AA017830 (The Mayo Clinic Center for Individualized Treatment of Alcohol Dependence), and the SC Johnson Genomics of Addiction Program. The study drug for the original re- search study was provided by Forest Pharmaceuticals. This manuscript presents analyses based on data collected prior to initiation of acamprosate treatment. The National Institute on Alcohol Abuse and Alcoholism, SC Johnson Genomics of Addictions Program, and Forest Pharmaceuticals, Inc., or its affiliates, had no role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; nor in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Aims: We aimed to assess the prevalence of sleep disturbance in early alcohol recovery and its association with psychiatric comorbidity, cravings, propensity and severity of alcohol consumption. Design: The sample consisted of 18–80 year old patients (n = 303) receiving treatment for alcohol dependence. Sleep disturbance was measured using the Pittsburgh Sleep Quality Index (PSQI). Additional measures included PHQ-9, GAD-7 and Penn alcohol cravings scale (PACS), Inventory of Drug Taking Situations (IDTS) and alcohol consumption was measured utilizing the Time Line Follow Back (TLFB).Bivariate analyses evaluated the association between PSQI total score and other clinical characteristics. A multivariable model was computed for sleep disturbance with predictors entered into the model using automated stepwise selection. Findings: The sample was majority male (66%), White (93%) with a mean age of 42.2 ± 11.6 years. Baseline PSQI score was 10.2 ± 4.13 and most subjects (88%) reported sleep disturbance at baseline. Baseline sleep disturbance was associated with depressive symptoms (p < .0001), anxiety symptoms (p < .0001), craving (p < .0001), propensity to drink when experiencing unpleasant emotions (p < .0001), physical discomfort (p < .0001), loss of personal control (p = 0.03), conflict (p = 0.002), number of drinks consumed (p = 0.004), drinking days (p = 0.004) and hazardous drinking days (p = 0.03) in bivariate analyses. However, in the multivariable model, only PHQ-9 total score and IDTS physical discomfort subscale were associated with sleep disturbance. Conclusion: Sleep disruption is common in early alcohol recovery. Future studies should examine the prognostic and clinical implications of its association with current depressive symptoms and a propensity to drink while experiencing physical discomfort.
AB - Aims: We aimed to assess the prevalence of sleep disturbance in early alcohol recovery and its association with psychiatric comorbidity, cravings, propensity and severity of alcohol consumption. Design: The sample consisted of 18–80 year old patients (n = 303) receiving treatment for alcohol dependence. Sleep disturbance was measured using the Pittsburgh Sleep Quality Index (PSQI). Additional measures included PHQ-9, GAD-7 and Penn alcohol cravings scale (PACS), Inventory of Drug Taking Situations (IDTS) and alcohol consumption was measured utilizing the Time Line Follow Back (TLFB).Bivariate analyses evaluated the association between PSQI total score and other clinical characteristics. A multivariable model was computed for sleep disturbance with predictors entered into the model using automated stepwise selection. Findings: The sample was majority male (66%), White (93%) with a mean age of 42.2 ± 11.6 years. Baseline PSQI score was 10.2 ± 4.13 and most subjects (88%) reported sleep disturbance at baseline. Baseline sleep disturbance was associated with depressive symptoms (p < .0001), anxiety symptoms (p < .0001), craving (p < .0001), propensity to drink when experiencing unpleasant emotions (p < .0001), physical discomfort (p < .0001), loss of personal control (p = 0.03), conflict (p = 0.002), number of drinks consumed (p = 0.004), drinking days (p = 0.004) and hazardous drinking days (p = 0.03) in bivariate analyses. However, in the multivariable model, only PHQ-9 total score and IDTS physical discomfort subscale were associated with sleep disturbance. Conclusion: Sleep disruption is common in early alcohol recovery. Future studies should examine the prognostic and clinical implications of its association with current depressive symptoms and a propensity to drink while experiencing physical discomfort.
KW - Alcohol
KW - Craving
KW - Depression
KW - Insomnia
KW - Psychiatric comorbidity
KW - Sleep
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U2 - 10.1016/j.drugalcdep.2019.107655
DO - 10.1016/j.drugalcdep.2019.107655
M3 - Article
C2 - 31744670
AN - SCOPUS:85075435143
SN - 0376-8716
VL - 206
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
M1 - 107655
ER -