TY - JOUR
T1 - Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
AU - Nomura, Teruaki
AU - Khan, Md Matiullah
AU - Kaul, Sunil C.
AU - Dong, Hai Dong
AU - Wadhwa, Renu
AU - Colmenares, Clemencia
AU - Kohno, Isao
AU - Ishii, Shunsuke
PY - 1999/2/15
Y1 - 1999/2/15
N2 - The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRβ). The oncogenic form, v-Ski, which lacks the mSin3A-binding domain, acts in a dominant-negative fashion, and abrogates transcriptional repression by Mad and TRβ. In ski-deficient mouse embryos, the ornithine decarboxylase gene, whose expression is normally repressed by Mad-Max, is expressed ectopically. These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex. The involvement of c-Ski in the HDAC complex indicates that the function of the HDAC complex is important for oncogenesis.
AB - The N-CoR/SMRT complex containing mSin3 and histone deacetylase (HDAC) mediates transcriptional repression by nuclear hormone receptors and Mad. The proteins encoded by the ski proto-oncogene family directly bind to N-CoR/SMRT and mSin3A, and forms a complex with HDAC. c-Ski and its related gene product Sno are required for transcriptional repression by Mad and thyroid hormone receptor (TRβ). The oncogenic form, v-Ski, which lacks the mSin3A-binding domain, acts in a dominant-negative fashion, and abrogates transcriptional repression by Mad and TRβ. In ski-deficient mouse embryos, the ornithine decarboxylase gene, whose expression is normally repressed by Mad-Max, is expressed ectopically. These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex. The involvement of c-Ski in the HDAC complex indicates that the function of the HDAC complex is important for oncogenesis.
KW - Histone deacetylase complex
KW - Mad
KW - N-CoR/SMRT corepressor
KW - Ski
KW - mSin3
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U2 - 10.1101/gad.13.4.412
DO - 10.1101/gad.13.4.412
M3 - Article
C2 - 10049357
AN - SCOPUS:0033557497
SN - 0890-9369
VL - 13
SP - 412
EP - 423
JO - Genes and Development
JF - Genes and Development
IS - 4
ER -