Sirolimus-Associated Diffuse Alveolar Hemorrhage

Nicholas E. Vlahakis, Otis B. Rickman, Timothy Morgenthaler

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Sirolimus is an immunosuppressive medication used in transplant recipients. To our knowledge, we describe the third reported case of alveolar hemorrhage in association with sirolimus. Fever, dyspnea, hemoptysis, and lung infiltrates resolved rapidly with cessation of sirolimus therapy both initially and after reinstitution of the drug. Unlike previous reports, our patient had no evidence of lymphocytic alveolitis but rather marked macrophage hemosiderosis, suggesting that sirolimus pulmonary toxicity may manifest through 2 separate mechanisms. Our case highlights an uncommon but potentially lethal manifestation of sirolimus pulmonary toxicity.

Original languageEnglish (US)
Pages (from-to)541-545
Number of pages5
JournalMayo Clinic proceedings
Issue number4
StatePublished - Apr 2004

ASJC Scopus subject areas

  • General Medicine


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