Sinonasal adenocarcinoma: Population-based analysis of demographic and socioeconomic disparities

Christopher M. Low, Karthik Balakrishnan, Byron M. Smith, Janalee K. Stokken, Erin K. O'Brien, Jamie J. Van Gompel, Nicholas R. Rowan, Garret Choby

Research output: Contribution to journalArticlepeer-review


Background: Sinonasal adenocarcinoma (SNAC) is a rare tumor. The impact of health disparities on survival, stage at presentation, and utilization of surgery is not well understood in patients with SNAC. Methods: The Surveillance, Epidemiology, and End Results database was queried for cases of SNAC from 1973 to 2015. Cases were analyzed to assess for disparities in presentation, treatment, and survival. Results: SNAC was identified in 630 patients. In a multivariate model of overall survival, an age increase of 10 years (Hazard Ratio (HR) = 1.37, p < 0.001), male sex (HR = 1.26, p = 0.045), and more recent decade of diagnosis (HR = 0.74, p < 0.001) were significantly related to time-to-death. There is a higher rate of SNAC-related death in counties with more rural populations (p = 0.027). Conclusion: Future interventions targeting rural and less well-educated populations may improve care with the goal of increasing the span of healthy life and reducing survival disparities related to SNAC.

Original languageEnglish (US)
Pages (from-to)2946-2953
Number of pages8
JournalHead and Neck
Issue number10
StatePublished - Oct 2021


  • SEER
  • anterior skull base
  • disparities
  • endoscopic skull base surgery
  • health disparities
  • paranasal sinuses
  • rhinology
  • sinonasal
  • sinonasal adenocarcinoma
  • sinonasal malignancy

ASJC Scopus subject areas

  • Otorhinolaryngology


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