Sex, Cells, and Asthma

Sergio E. Chiarella, Juan Carlos Cardet, Y. S. Prakash

Research output: Contribution to journalReview articlepeer-review


There are marked sex differences in asthma prevalence and severity. Sex hormones play a central role in these sex biases and directly interact with multiple key cells involved in the pathogenesis of asthma. Here we review the known effects of estrogen, progesterone, and testosterone on airway epithelial cells, airway smooth muscle cells, the mononuclear phagocyte system, innate lymphoid cells, eosinophils, mast cells, T cells, and B cells, all in the context of asthma. Furthermore, we explore unresolved clinical questions, such as the role of sex hormones in the link between asthma and obesity.

Original languageEnglish (US)
Pages (from-to)1955-1969
Number of pages15
JournalMayo Clinic proceedings
Issue number7
StatePublished - Jul 2021

ASJC Scopus subject areas

  • Medicine(all)


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