Sesquiterpene lactones from Achillea crithmifolia

S. Milosavljevic; S. Macura; M. Stefanovic; I. Aljancic; D. Milinkovk

doi:10.1021/np50103a008

Sesquiterpene lactones from Achillea crithmifolia

S. Milosavljevic
, S. Macura
, M. Stefanovic
, I. Aljancic
, D. Milinkovk

Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The isolation of three highly oxygenated guaianolides, desacetyl-1α-4α- dihydroxybishopsolicepolide [1], its 4β-hydroxy epimer 2 (a new compound), and 1β,2β:3β,4β-diepoxy-8α,10α-dihydroxyguai-12(13)-en-12,6α-olide [3], from the aerial parts of Achillea crithmifolia is reported. Because lactone 3 was shown to be identical with rupin A, the initially proposed 1α,2α:3α,4α-diepoxy stereochemistry of rupin A should be revised.

Original language	English (US)
Pages (from-to)	64-67
Number of pages	4
Journal	Journal of Natural Products
Volume	57
Issue number	1
DOIs	https://doi.org/10.1021/np50103a008
State	Published - 1994

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50103a008

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@article{b559622e345e48998afc0b6bc9905c94,

title = "Sesquiterpene lactones from Achillea crithmifolia",

abstract = "The isolation of three highly oxygenated guaianolides, desacetyl-1α-4α- dihydroxybishopsolicepolide [1], its 4β-hydroxy epimer 2 (a new compound), and 1β,2β:3β,4β-diepoxy-8α,10α-dihydroxyguai-12(13)-en-12,6α-olide [3], from the aerial parts of Achillea crithmifolia is reported. Because lactone 3 was shown to be identical with rupin A, the initially proposed 1α,2α:3α,4α-diepoxy stereochemistry of rupin A should be revised.",

author = "S. Milosavljevic and S. Macura and M. Stefanovic and I. Aljancic and D. Milinkovk",

note = "Funding Information: Acknawiedgements--This project has been subsidized by the National Program of Pharmaceutical Research and Development (No. FAR88-00501), Gobierno de Canarias (No. 12/32.07.89)a nd AXETI. Funding Information: Acknowledgements-Thea uthors are very grateful to the Serbian Academyo f Sciencea nd Arts, and to the Serbian Republic ResearchF und for financial support. We wish to acknowledgoeu rg ratitudeto Professor3 .L . Markleyf or theu se of theN MR facilitya t theD epartmenot f BiochemistryU, niver-sity of Wisconsin,M adison,U .S.A.",

year = "1994",

doi = "10.1021/np50103a008",

language = "English (US)",

volume = "57",

pages = "64--67",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Sesquiterpene lactones from Achillea crithmifolia

AU - Milosavljevic, S.

AU - Macura, S.

AU - Stefanovic, M.

AU - Aljancic, I.

AU - Milinkovk, D.

N1 - Funding Information: Acknawiedgements--This project has been subsidized by the National Program of Pharmaceutical Research and Development (No. FAR88-00501), Gobierno de Canarias (No. 12/32.07.89)a nd AXETI. Funding Information: Acknowledgements-Thea uthors are very grateful to the Serbian Academyo f Sciencea nd Arts, and to the Serbian Republic ResearchF und for financial support. We wish to acknowledgoeu rg ratitudeto Professor3 .L . Markleyf or theu se of theN MR facilitya t theD epartmenot f BiochemistryU, niver-sity of Wisconsin,M adison,U .S.A.

PY - 1994

Y1 - 1994

N2 - The isolation of three highly oxygenated guaianolides, desacetyl-1α-4α- dihydroxybishopsolicepolide [1], its 4β-hydroxy epimer 2 (a new compound), and 1β,2β:3β,4β-diepoxy-8α,10α-dihydroxyguai-12(13)-en-12,6α-olide [3], from the aerial parts of Achillea crithmifolia is reported. Because lactone 3 was shown to be identical with rupin A, the initially proposed 1α,2α:3α,4α-diepoxy stereochemistry of rupin A should be revised.

AB - The isolation of three highly oxygenated guaianolides, desacetyl-1α-4α- dihydroxybishopsolicepolide [1], its 4β-hydroxy epimer 2 (a new compound), and 1β,2β:3β,4β-diepoxy-8α,10α-dihydroxyguai-12(13)-en-12,6α-olide [3], from the aerial parts of Achillea crithmifolia is reported. Because lactone 3 was shown to be identical with rupin A, the initially proposed 1α,2α:3α,4α-diepoxy stereochemistry of rupin A should be revised.

UR - https://www.scopus.com/pages/publications/0028280593

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DO - 10.1021/np50103a008

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SN - 0163-3864

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EP - 67

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

Sesquiterpene lactones from Achillea crithmifolia

Abstract

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