Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease

David H. Dockrell; Jose Prada; Mary F. Joncs; Robin Patel; Andrew D. Badley; William S. Harmsen; Duane M. Ilstrup; Russell H. Wiesner; Ruud A.F. Krom; Thomas F. Smith; Carlos V. Paya

doi:10.1086/514104

Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease

David H. Dockrell, Jose Prada, Mary F. Joncs, Robin Patel, Andrew D. Badley, William S. Harmsen, Duane M. Ilstrup, Russell H. Wiesner, Ruud A.F. Krom, Thomas F. Smith, Carlos V. Paya

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106 Scopus citations

Abstract

Human herpesvirus 6 (HHV-6) infection is common after transplantation; HHV-6 is known to interact with other viruses and induce immunosuppression. Whether HHV-6 plays a role in the occurrence of cytomegalovirus (CMV) infection after transplantation was investigated. In a cohort of 247 liver transplant recipients, HHV-6 seroconversion was identified as a significant risk factor for development of symptomatic CMV infection (P < .001), including CMV organ involvement (P < .001), even in the presence of the other significant risk factors: D⁺/R^- CMV serologic status (P < .001) or use of OKT3 after transplantation (P = .002). Subgroup analysis indicated that HHV- 6 seroconversion was significantly associated with symptomatic CMV infection in the D⁺/R⁺ but not in the D⁺/R^- CMV serologic group (P < .001 and P = .11, respectively). These results indicate that HHV-6 seroconversion is a marker for CMV disease after transplantation and suggest that additional studies using more sensitive diagnostic techniques are warranted to determine the relationship between HHV-6 and CMV infection after transplantation.

Original language	English (US)
Pages (from-to)	1135-1140
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	176
Issue number	5
DOIs	https://doi.org/10.1086/514104
State	Published - 1997

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Medicine(all)

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@article{46d8d617f95944e3b1ad01ff99f78e6a,

title = "Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease",

abstract = "Human herpesvirus 6 (HHV-6) infection is common after transplantation; HHV-6 is known to interact with other viruses and induce immunosuppression. Whether HHV-6 plays a role in the occurrence of cytomegalovirus (CMV) infection after transplantation was investigated. In a cohort of 247 liver transplant recipients, HHV-6 seroconversion was identified as a significant risk factor for development of symptomatic CMV infection (P < .001), including CMV organ involvement (P < .001), even in the presence of the other significant risk factors: D+/R- CMV serologic status (P < .001) or use of OKT3 after transplantation (P = .002). Subgroup analysis indicated that HHV- 6 seroconversion was significantly associated with symptomatic CMV infection in the D+/R+ but not in the D+/R- CMV serologic group (P < .001 and P = .11, respectively). These results indicate that HHV-6 seroconversion is a marker for CMV disease after transplantation and suggest that additional studies using more sensitive diagnostic techniques are warranted to determine the relationship between HHV-6 and CMV infection after transplantation.",

author = "Dockrell, {David H.} and Jose Prada and Joncs, {Mary F.} and Robin Patel and Badley, {Andrew D.} and Harmsen, {William S.} and Ilstrup, {Duane M.} and Wiesner, {Russell H.} and Krom, {Ruud A.F.} and Smith, {Thomas F.} and Paya, {Carlos V.}",

year = "1997",

doi = "10.1086/514104",

language = "English (US)",

volume = "176",

pages = "1135--1140",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease

AU - Dockrell, David H.

AU - Prada, Jose

AU - Joncs, Mary F.

AU - Patel, Robin

AU - Badley, Andrew D.

AU - Harmsen, William S.

AU - Ilstrup, Duane M.

AU - Wiesner, Russell H.

AU - Krom, Ruud A.F.

AU - Smith, Thomas F.

AU - Paya, Carlos V.

PY - 1997

Y1 - 1997

N2 - Human herpesvirus 6 (HHV-6) infection is common after transplantation; HHV-6 is known to interact with other viruses and induce immunosuppression. Whether HHV-6 plays a role in the occurrence of cytomegalovirus (CMV) infection after transplantation was investigated. In a cohort of 247 liver transplant recipients, HHV-6 seroconversion was identified as a significant risk factor for development of symptomatic CMV infection (P < .001), including CMV organ involvement (P < .001), even in the presence of the other significant risk factors: D+/R- CMV serologic status (P < .001) or use of OKT3 after transplantation (P = .002). Subgroup analysis indicated that HHV- 6 seroconversion was significantly associated with symptomatic CMV infection in the D+/R+ but not in the D+/R- CMV serologic group (P < .001 and P = .11, respectively). These results indicate that HHV-6 seroconversion is a marker for CMV disease after transplantation and suggest that additional studies using more sensitive diagnostic techniques are warranted to determine the relationship between HHV-6 and CMV infection after transplantation.

AB - Human herpesvirus 6 (HHV-6) infection is common after transplantation; HHV-6 is known to interact with other viruses and induce immunosuppression. Whether HHV-6 plays a role in the occurrence of cytomegalovirus (CMV) infection after transplantation was investigated. In a cohort of 247 liver transplant recipients, HHV-6 seroconversion was identified as a significant risk factor for development of symptomatic CMV infection (P < .001), including CMV organ involvement (P < .001), even in the presence of the other significant risk factors: D+/R- CMV serologic status (P < .001) or use of OKT3 after transplantation (P = .002). Subgroup analysis indicated that HHV- 6 seroconversion was significantly associated with symptomatic CMV infection in the D+/R+ but not in the D+/R- CMV serologic group (P < .001 and P = .11, respectively). These results indicate that HHV-6 seroconversion is a marker for CMV disease after transplantation and suggest that additional studies using more sensitive diagnostic techniques are warranted to determine the relationship between HHV-6 and CMV infection after transplantation.

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Seroconversion to human herpesvirus 6 following liver transplantation is a marker of cytomegalovirus disease

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