Serious infections caused by methicillin-resistant Staphylococcus aureus

Helen Boucher, Loren G. Miller, Raymund R. Razonable

Research output: Contribution to journalReview articlepeer-review

178 Scopus citations


Although first identified just >4 decades ago, methicillin-resistant Staphylococcus aureus (MRSA) has undergone rapid evolutionary changes and epidemiologic expansion to become a major cause of nosocomial and community-acquired infections worldwide. Increasing resistance to vancomycin among MRSA strains in conjunction with availability of new antibiotics, including daptomycin and linezolid, have increased treatment choices but made clinical treatment decisions more challenging. This article describes the clinical features and management issues of 2 challenging-to-treat manifestations of MRSA infection, bacteremia and/or endocarditis and osteomyelitis. It also presents a brief review of community-associated MRSA infections and preventive strategies directed against MRSA.

Original languageEnglish (US)
Pages (from-to)S183-S197
JournalClinical Infectious Diseases
Issue numberSUPPL. 2
StatePublished - Sep 15 2010

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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